Jul 15, 2013 · Adult Hirschsprung’s disease (HD) is a rare motor disorder of the gut that is frequently misdiagnosed as refractory constipation. The primary pathogenic defect in adult HD is identical to that seen in infancy or childhood, and is characterized by the total absence of intramural ganglion cells of the submucosal (Meissner) and myenteric (Auerbach) neural plexuses in the affected segment of the bowel.Cited by: 3.
Adult Hirschsprung’s disease although uncommon is diagnosed with a high index of suspicion in a patient with recurrent constipation, history of delayed passage of meconium and aganglionosis on rectal biopsy. Staged resection and endorectal pull-through provide good outcome.
Review of 199 cases of adult Hirschsprung's disease enables comparison of the various operative procedures for this disorder with respect to postoperative complications and functional outcomes.