Hypoglycemia due to an adult-onset nesidioblastosis, a diagnostic and management dilemma - adult nesidioblastosis

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Nesidioblastosis in adults. adult nesidioblastosis


In Adults, hyperinsulinemic hypoglycemia is mainly caused by insulinomas, other causes are rare and usually due to adult-onset nesidioblastosis, which was first described in 1975. Since then fewer than 100 cases have been reported but it seems to be increasing in frequency.

Nesidioblastosis is a rare cause of persistent hyperinsulinemic hypoglycemia in adults. The incidence of nesidioblastosis in adults is unknown, but it is generally thought to be very low. The β cell changes in adult nesidioblastosis suggest a dysregulation of the function of the cell. The cause of the functional dysregulation in adults is unknown.Cited by: 4.

Context. Nesidioblastosis is a rare cause of hyperinsulinemic hypoglycemia in adults. The diagnosis is further complicated in patients with kidney failure, since impaired renal function can cause hypoglycemia by itself and diagnostic criteria for this clinical scenario have not been developed yet. Case Description. We present the case report of a 36-year-old patient with end stage chronic Author: Eduardo Lozano-Melendez, Mercedes Aguilar-Soto, Luis Eugenio Graniel-Palafox, Laura Elena Ceceña-Mar.